Welcome to the Bioinformatics and Analytics Research Collaborative (BARC)
Open to all, focused on unmet need
Abstract Imatinib is a kinase inhibitor used in the treatment of chronic myeloid leukemia (CML) and other cancers. Although its pharmacokinetics are generally predictable, substantial interindividual variability in clearance and exposure remains. In this study, we investigated the impact of cytochrome P450 (CYP) enzymes: CYP2C8, CYP3A4, and CYP3A5 phenotypes and genotypes on imatinib metabolism using … Read more
Abstract Sulfamethoxazole (SMX) is associated with idiosyncratic drug induced liver injury (DILI), which remains difficult to predict. SMX is metabolized by N-acetyltransferases (NAT1/NAT2) to form N4-acetyl sulfamethoxazole (NA-SMX), and by cytochrome P450-mediated oxidation to form SMX-hydroxylamine (SMX-HA). This study aimed to characterize SMX metabolism in vitro and investigate how NAT1 and NAT2 variation influences NA-SMX formation, including the relationship between NAT2 protein levels … Read more
Abstract Adeno-associated virus (AAV) gene therapies typically use constitutive transgene expression vectors that cannot be altered after vector administration. Here, we describe a bioorthogonal platform for tuning AAV expression which enables the controlled activation of viral transgenes after transduction. This platform uses a small, synthetic DNA-binding protein embedded in the AAV genome coupled with a … Read more
About Us
The Bioinformatics and Analytics Research Collaborative (BARC) at the University of North Carolina at Chapel Hill is a multi disciplinary center that aims to provide bioinformatics expertise and analysis to researchers across the university and beyond for high throughput data. We analyze, visualize, interpret, and manage big data while also offering custom solutions to fit our researchers’ needs. Additionally, the center strives to educate researchers on current tools and techniques, foster a collaborative environment by hosting workshops, working groups, and seminars, and improve existing tools and/or invent new tools and algorithms.
How We Work
We offer a free initial consultation for incoming projects during which we discuss the client’s project and how to ensure they are able to maximize the information that they learn. Afterwards, depending on the scale of the project we provide services by the hours or staff for grant for projects longer than six months. Each project is assigned to a project coordinator and bioinformaticist. The project coordinator is the point of contact for the client and is responsible for updating them on the status of their project.
